Content

Reviewed By
Phillip Azouz, MD
Written by
Phillip Azouz, MD
Published
September 07, 2026
Updated
April 20, 2026

One of the most common concerns before starting GLP-1 treatment is side effects. Understanding which are normal, which are temporary, and which warrant a provider conversation makes the early weeks much less stressful.

Common Side Effects That Are Usually Temporary

  • Mild nausea — especially the first few days after a new dose of semaglutide or tirzepatide
  • Digestive changes — loose stools, constipation, or bloating
  • Reduced appetite — this is actually an intended effect
  • Fatigue — often temporary as your body recalibrates

Tips for Managing Early Side Effects

  • Eat smaller, more frequent meals rather than large portions
  • Avoid fatty, fried, or heavily spiced foods during the adjustment period
  • Stay well hydrated — dehydration worsens nausea
  • Take your injection at the same time each week

When to Contact Your Provider

  • Severe or persistent vomiting making eating or drinking difficult
  • Significant abdominal pain
  • Mood or mental health changes that feel significant

Medical Oversight Makes the Difference

At HolaVida, your licensed provider monitors progress throughout treatment and can adjust dosing to improve comfort. Visit HolaVida for support.

Ready to get started? Review our plans and begin your consultation today

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