Content

Reviewed By
Dr. Phillip Azouz
Written by
Dr. Phillip Azouz
Published
November 11, 2025
Updated
November 12, 2025

What Not to Eat on GLP-1s: Foods That Can Worsen Side Effects

When you first begin GLP-1s treatment, with medications like Semaglutide or Tirzepatide, it’s normal to experience a few digestive changes—after all, these medications work by slowing how quickly your stomach empties. But certain foods can make those effects feel much stronger, leading to nausea, bloating, or discomfort.

Avoiding those “trigger” foods early on can help your body adjust smoothly and keep you feeling good. Think of it as giving your stomach a break while your metabolism recalibrates. By choosing lighter, cleaner meals and staying mindful of what doesn’t sit well, you’ll likely notice that your energy improves and your appetite feels more balanced day by day.

Avoid or Limit:

  • Fried or greasy foods – Harder to digest and may trigger nausea

  • Spicy foods – Can irritate your stomach

  • Sugary drinks – Cause blood sugar spikes and cravings

  • Alcohol – Dehydrates and worsens nausea

  • Large, heavy meals – Overfill your stomach when digestion is already slowed

Small, mindful meals with gentle foods keep your digestion comfortable. Listen to your body—it’ll tell you what feels right.

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What to Expect During Your First Month on GLP-1s

Intro: Starting GLP-1 medications like Semaglutide or Tirzepatide is an exciting step toward better health—but it can also come with a few unknowns. During the first month, your body is adjusting to a new rhythm: your appetite changes, your digestion slows, and your energy may fluctuate as your system learns to balance blood sugar and hunger cues.