Content

Reviewed By
Dr. Phillip Azouz
Written by
Dr. Phillip Azouz
Published
December 09, 2025
Updated
December 9, 2025

What to Expect During Your First Month on GLP-1s

Intro:


Starting GLP-1 medications like Semaglutide or Tirzepatide is an exciting step toward better health—but it can also come with a few unknowns. During the first month, your body is adjusting to a new rhythm: your appetite changes, your digestion slows, and your energy may fluctuate as your system learns to balance blood sugar and hunger cues.

Understanding what’s normal (and what’s not) helps you stay calm and confident through those early weeks. You might notice subtle shifts in how food tastes, how quickly you feel full, or even your sleep patterns. By setting realistic expectations and listening to your body, you’ll be able to manage the adjustment period with ease—and set yourself up for long-term success.

Week-by-Week Overview:

  • Week 1–2: Appetite drops, mild nausea possible. Eat slowly and hydrate

  • Week 3: Energy stabilizes, fullness sets in faster. Focus on protein

  • Week 4: Weight changes become visible. Digestive rhythm normalizes

Pro Tips:

  • Eat smaller meals

  • Avoid alcohol early on

  • Keep track of symptoms and progress

Closing:


Every patient is different. Stay in touch with your provider and celebrate every small win—you’re building momentum.

Related Conditions

GLP-1
October 24, 2025

Why Weight Loss Looks Different for Everyone on GLP-1s

If you’ve ever compared your progress to someone else’s and wondered why your results look different—don’t worry, that’s completely normal. Weight loss on GLP-1s, with medications like Semaglutide or Tirzepatide, is a deeply personal experience, shaped by everything from your genetics and hormones to your sleep, stress, and nutrition habits.

GLP-1
October 24, 2025

The Science Behind GLP-1s: How These Medications Actually Work

Intro: GLP-1 medications like Semaglutide and Tirzepatide have become game-changers in modern healthcare—but how do they really work? The answer lies in your body’s natural biology. GLP-1 stands for glucagon-like peptide-1, a hormone your gut releases after eating that tells your brain, “I’m full.” It also helps regulate blood sugar and digestion.

GLP-1
October 24, 2025

What to Expect During Your First Month on GLP-1s

Intro: Starting GLP-1 medications like Semaglutide or Tirzepatide is an exciting step toward better health—but it can also come with a few unknowns. During the first month, your body is adjusting to a new rhythm: your appetite changes, your digestion slows, and your energy may fluctuate as your system learns to balance blood sugar and hunger cues.